High-Purity Fluorinated Reagents for Peptide and Pharmaceutical Chemistry

From early research through to larger-scale production, pharmaceutical synthesis depends on reagents that perform consistently and fit reliably into established workflows. 

Halocarbon offers BioGrade^® Trifluoroacetic Acid (TFA) and Trifluoroacetic Anhydride (TFAA) for peptide and oligonucleotide synthesis, pharmaceutical molecule development, chromatography, and fluorinated building-block chemistry. 

Halocarbon BioGrade^® Trifluoroacetic Acid (TFA) 

Halocarbon BioGrade^® TFA is an ultra-high-purity grade of trifluoroacetic acid developed for peptide and protein research where low impurity levels and low non-volatile residue are important. 

It is supplied with a minimum assay of 99.9% and can be used directly from the bottle without further purification. 

Applications 

• Peptide cleavage and protecting-group removal 

• Deprotection of Boc and Bzl protecting groups 

• Cleavage of Fmoc and tBut protecting groups 

• Peptide synthesis and purification 

• HPLC analysis of peptides and small proteins 

• Laboratory-scale procedures through to manufacturing-scale peptide synthesis 

Its combination of acid strength, volatility, and solubility supports protection, deprotection, and purification stages in peptide workflows. 

Halocarbon Trifluoroacetic Anhydride (TFAA) 

Halocarbon TFAA is a reactive fluorinated anhydride used to introduce trifluoromethyl functionality into organic compounds. It is used in the production of pharmaceutical molecules and is also widely used in chromatography. 

Applications 

• Pharmaceutical molecule production 

• Peptide and oligonucleotide synthesis 

• Organic synthesis 

• Gas and liquid chromatography 

• Trifluoro acylation reactions involving alcohols, amines, and phenols 

• Esterification and transesterification promotion 

• Condensation reactions 

TFAA is the most reactive and volatile of the anhydrides and provides a practical route for introducing fluorinated functionality into more complex molecules. 

Support for fluorinated pharmaceutical building blocks

Halocarbon positions TFA and its derivatives as starting materials for fluorinated compounds, including intermediates for pharmaceutical APIs. Together, BioGrade^® TFA and TFAA offer complementary options for peptide chemistry, chromatography, and the development of fluorinated pharmaceutical intermediates.

Speak with our experts

Are you looking for Halocarbon BioGrade^® TFA or Halocarbon Trifluoroacetic Anhydride (TFAA) for peptide synthesis, chromatography, or the development of pharmaceutical intermediates?

Consult with our experts to discuss the right Halocarbon product for your application.