Ashland BiotHAIRapy™ For Better-Looking Hair

BiotHAIRapy™ biofunctionals are a family of ingredients with dedicated capabilities for hair roots. These nature-based products address hair aging by supporting natural follicle and strand organization in ways that improve the appearance of hair. BiotHAIRapy™ ingredients are ideal for leave-in hair care products for hair density, strength, growth, detox, and natural color protection.

Capauxein™ G2 for Hair Density

INCI: Water (and) Glycerin (and) Hydrolyzed Corn Protein (and) Adenosine (and) Magnesium Ascorbyl Phosphate (and) Carnitine

Capauxein™ G2 Benefits:

An increase in key biomarkers
  • Ki67 and β1-integrin, markers of proliferation and communication respectively (in vitro, ex vivo)
  • Versican and noggin, highly expressed during the anagen phase in the dermal papilla (3D-spheres)

Visible benefits on 39 panellists
  • A healthier scalp with less visible oiliness and more hydration (in vivo)
  • Visible maintenance of the anagen phase (in vivo)
  • Visible improvement of hair density and fullness (in vivo)

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Chromafend™ for Natural Hair Color Protection

INCI: Aqua (and) Glycerin (and) Hydrolyzed Linseed Extract

Chromafend™ Benefits:

An increase in key biomarkers
  • Tyrosinase, an enzyme involved in melanin production (in vitro, ex vivo)
  • TRP-1, a marker known to participate in melanin synthesis (in vitro)
  • Pmel 17 associated with favorable conditions for melanin synthesis (in vitro)
  • MITF known to regulate melanin synthesis (in vitro)
  • C-kit associated with melanin process (in vitro)
  • PAR-2 associated with the transfer melanin into keratinocytes (in vitro)
  • Chromafend™ is associated with increased melanin in the hair cortex (ex vivo)

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Dynagen™ for Hair Strength

INCI: Aqua (and) Glycerin (and) Hydrolyzed Yeast Protein

Dynagen™ Benefits:
  • Consumer-perceivable benefit for stronger, thicker, healthier hair feel (in vivo)
  • Increase in key protein markers, keratin 14, keratin 17, keratin 71, trichohyalin (ex vivo), all of which are associated with minimization of hair fall
  • Increase in collagen I (ex vivo)
  • Increase in collagen IV and CD34 (ex vivo) associated with healthy appearance of the hair

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Procataline™ G2 for Hair Detox

INCI: Water (and) Glycerin (and) Pisum Sativum (Pea) Extract (and) Salvia Hispanica Seed Extract

Procataline™ G2 Benefits:

Sheltering hair from air pollutants (in vitro, ex vivo)
  • Helps chelate heavy metals
  • Helps reduce hair damage when exposed to air pollutants sheltering hair roots from air pollutants
  • Visibly helps increase the antioxidant defenses (catalase enzyme) in scalp cells
  • Visibly reduces the pollution marker AhR/CYP1A1 and the IL1-R1 response triggered by air pollutants
  • Helps limit the visible impact of major air pollutants on VEGFA microcirculation marker and Sox9 stem cells marker

Sheltering scalp from air pollutants (in vivo)
  • Visibly reduces stratum corneum oxidative damage
  • Helps increase scalp hydration and barrier function
  • Contributes to balance scalp oiliness
  • Helps decrease scalp flakes and redness
  • Visibly reduces scalp irritation

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Protectagen™ for Hair Growth

INCI: Aqua (and) Glycerin (and) Hydrolyzed Rice Protein

Protectagen™ Benefits:
  • Increased stem cell markers, keratin 15, β6-Integrin, β-Catenin and p63, key to the maintenance of hair growth capital (ex vivo)
  • Helps preserve hair follicle against harmful UV damage, evidenced by the lower expression of p53 markers (ex vivo)
  • Improved appearance of hair length (ex vivo)

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