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    BiotHAIRapy™ biofunctionals are a family of ingredients with dedicated capabilities for hair roots. These nature-based products address hair aging by supporting natural follicle and strand organization in ways that improve the appearance of hair. BiotHAIRapy™ ingredients are ideal for leave-in hair care products for hair density, strength, growth, detox, and natural color protection.
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    Capauxein™ G2 for Hair Density


    INCI: Water (and) Glycerin (and) Hydrolyzed Corn Protein (and) Adenosine (and) Magnesium Ascorbyl Phosphate (and) Carnitine

    Capauxein™ G2 Benefits:

    An increase in key biomarkers
    • Ki67 and β1-integrin, markers of proliferation and communication respectively (in vitro, ex vivo)
    • Versican and noggin, highly expressed during the anagen phase in the dermal papilla (3D-spheres)

    Visible benefits on 39 panellists
    • A healthier scalp with less visible oiliness and more hydration (in vivo)
    • Visible maintenance of the anagen phase (in vivo)
    • Visible improvement of hair density and fullness (in vivo)

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    Chromafend™ for Natural Hair Color Protection


    INCI: Aqua (and) Glycerin (and) Hydrolyzed Linseed Extract

    Chromafend™ Benefits:

    An increase in key biomarkers
    • Tyrosinase, an enzyme involved in melanin production (in vitro, ex vivo)
    • TRP-1, a marker known to participate in melanin synthesis (in vitro)
    • Pmel 17 associated with favorable conditions for melanin synthesis (in vitro)
    • MITF known to regulate melanin synthesis (in vitro)
    • C-kit associated with melanin process (in vitro)
    • PAR-2 associated with the transfer melanin into keratinocytes (in vitro)
    • Chromafend™ is associated with increased melanin in the hair cortex (ex vivo)

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    Dynagen™ for Hair Strength


    INCI: Aqua (and) Glycerin (and) Hydrolyzed Yeast Protein

    Dynagen™ Benefits:
    • Consumer-perceivable benefit for stronger, thicker, healthier hair feel (in vivo)
    • Increase in key protein markers, keratin 14, keratin 17, keratin 71, trichohyalin (ex vivo), all of which are associated with minimization of hair fall
    • Increase in collagen I (ex vivo)
    • Increase in collagen IV and CD34 (ex vivo) associated with healthy appearance of the hair

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    Procataline™ G2 for Hair Detox


    INCI: Water (and) Glycerin (and) Pisum Sativum (Pea) Extract (and) Salvia Hispanica Seed Extract

    Procataline™ G2 Benefits:

    Sheltering hair from air pollutants (in vitro, ex vivo)
    • Helps chelate heavy metals
    • Helps reduce hair damage when exposed to air pollutants sheltering hair roots from air pollutants
    • Visibly helps increase the antioxidant defenses (catalase enzyme) in scalp cells
    • Visibly reduces the pollution marker AhR/CYP1A1 and the IL1-R1 response triggered by air pollutants
    • Helps limit the visible impact of major air pollutants on VEGFA microcirculation marker and Sox9 stem cells marker

    Sheltering scalp from air pollutants (in vivo)
    • Visibly reduces stratum corneum oxidative damage
    • Helps increase scalp hydration and barrier function
    • Contributes to balance scalp oiliness
    • Helps decrease scalp flakes and redness
    • Visibly reduces scalp irritation

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    Protectagen™ for Hair Growth


    INCI: Aqua (and) Glycerin (and) Hydrolyzed Rice Protein

    Protectagen™ Benefits:
    • Increased stem cell markers, keratin 15, β6-Integrin, β-Catenin and p63, key to the maintenance of hair growth capital (ex vivo)
    • Helps preserve hair follicle against harmful UV damage, evidenced by the lower expression of p53 markers (ex vivo)
    • Improved appearance of hair length (ex vivo)

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