

BiotHAIRapy™ biofunctionals are a family of ingredients with dedicated capabilities for hair roots. These nature-based products address hair aging by supporting natural follicle and strand organization in ways that improve the appearance of hair. BiotHAIRapy™ ingredients are ideal for leave-in hair care products for hair density, strength, growth, detox, and natural color protection.


- Ki67 and β1-integrin, markers of proliferation and communication respectively (in vitro, ex vivo)
- Versican and noggin, highly expressed during the anagen phase in the dermal papilla (3D-spheres)
- A healthier scalp with less visible oiliness and more hydration (in vivo)
- Visible maintenance of the anagen phase (in vivo)
- Visible improvement of hair density and fullness (in vivo)


Capauxein™ G2 for Hair Density
INCI: Water (and) Glycerin (and) Hydrolyzed Corn Protein (and) Adenosine (and) Magnesium Ascorbyl Phosphate (and) Carnitine
Capauxein™ G2 Benefits:
An increase in key biomarkers
Visible benefits on 39 panellists
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- Tyrosinase, an enzyme involved in melanin production (in vitro, ex vivo)
- TRP-1, a marker known to participate in melanin synthesis (in vitro)
- Pmel 17 associated with favorable conditions for melanin synthesis (in vitro)
- MITF known to regulate melanin synthesis (in vitro)
- C-kit associated with melanin process (in vitro)
- PAR-2 associated with the transfer melanin into keratinocytes (in vitro)
- Chromafend™ is associated with increased melanin in the hair cortex (ex vivo)


Chromafend™ for Natural Hair Color Protection
INCI: Aqua (and) Glycerin (and) Hydrolyzed Linseed Extract
Chromafend™ Benefits:
An increase in key biomarkers
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- Consumer-perceivable benefit for stronger, thicker, healthier hair feel (in vivo)
- Increase in key protein markers, keratin 14, keratin 17, keratin 71, trichohyalin (ex vivo), all of which are associated with minimization of hair fall
- Increase in collagen I (ex vivo)
- Increase in collagen IV and CD34 (ex vivo) associated with healthy appearance of the hair


Dynagen™ for Hair Strength
INCI: Aqua (and) Glycerin (and) Hydrolyzed Yeast Protein
Dynagen™ Benefits:
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- Helps chelate heavy metals
- Helps reduce hair damage when exposed to air pollutants sheltering hair roots from air pollutants
- Visibly helps increase the antioxidant defenses (catalase enzyme) in scalp cells
- Visibly reduces the pollution marker AhR/CYP1A1 and the IL1-R1 response triggered by air pollutants
- Helps limit the visible impact of major air pollutants on VEGFA microcirculation marker and Sox9 stem cells marker
- Visibly reduces stratum corneum oxidative damage
- Helps increase scalp hydration and barrier function
- Contributes to balance scalp oiliness
- Helps decrease scalp flakes and redness
- Visibly reduces scalp irritation


Procataline™ G2 for Hair Detox
INCI: Water (and) Glycerin (and) Pisum Sativum (Pea) Extract (and) Salvia Hispanica Seed Extract
Procataline™ G2 Benefits:
Sheltering hair from air pollutants (in vitro, ex vivo)
Sheltering scalp from air pollutants (in vivo)
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- Increased stem cell markers, keratin 15, β6-Integrin, β-Catenin and p63, key to the maintenance of hair growth capital (ex vivo)
- Helps preserve hair follicle against harmful UV damage, evidenced by the lower expression of p53 markers (ex vivo)
- Improved appearance of hair length (ex vivo)


Protectagen™ for Hair Growth
INCI: Aqua (and) Glycerin (and) Hydrolyzed Rice Protein
Protectagen™ Benefits:
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Sample Formulations |
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City Shielf Ultra-Light Styling Lotion - Features Procataline™ G2 Color Shield! Weightless Leave-in Conditioner - Features Chromafend™ Conditioning Spray Milk - Features Dynagen™ Plentitude Hair Serum - Features Capauxein™ Strengthen It! Hair and Scalp Cream - Features Dynagen™ Youthful! Hair Yogurt - Features Chromafend™ |