Ashland™ BiotHAIRapy™ For Better-Looking Hair

Capauxein™ G2 for Hair Density

• Ki67 and β1-integrin, markers of proliferation and communication respectively (in vitro, ex vivo)
• Versican and noggin, highly expressed during the anagen phase in the dermal papilla (3D-spheres)

• A healthier scalp with less visible oiliness and more hydration (in vivo)
• Visible maintenance of the anagen phase (in vivo)
• Visible improvement of hair density and fullness (in vivo)

Chromafend™ for Natural Hair Color Protection

• Tyrosinase, an enzyme involved in melanin production (in vitro, ex vivo)
• TRP-1, a marker known to participate in melanin synthesis (in vitro)
• Pmel 17 associated with favorable conditions for melanin synthesis (in vitro)
• MITF known to regulate melanin synthesis (in vitro)
• C-kit associated with melanin process (in vitro)
• PAR-2 associated with the transfer melanin into keratinocytes (in vitro)
• Chromafend™ is associated with increased melanin in the hair cortex (ex vivo)

Dynagen™ for Hair Strength

• Consumer-perceivable benefit for stronger, thicker, healthier hair feel (in vivo)
• Increase in key protein markers, keratin 14, keratin 17, keratin 71, trichohyalin (ex vivo), all of which are associated with minimization of hair fall
• Increase in collagen I (ex vivo)
• Increase in collagen IV and CD34 (ex vivo) associated with healthy appearance of the hair

Procataline™ G2 for Hair Detox

• Helps chelate heavy metals
• Helps reduce hair damage when exposed to air pollutants sheltering hair roots from air pollutants
• Visibly helps increase the antioxidant defenses (catalase enzyme) in scalp cells
• Visibly reduces the pollution marker AhR/CYP1A1 and the IL1-R1 response triggered by air pollutants
• Helps limit the visible impact of major air pollutants on VEGFA microcirculation marker and Sox9 stem cells marker

• Visibly reduces stratum corneum oxidative damage
• Helps increase scalp hydration and barrier function
• Contributes to balance scalp oiliness
• Helps decrease scalp flakes and redness
• Visibly reduces scalp irritation

Protectagen™ for Hair Growth

• Increased stem cell markers, keratin 15, β6-Integrin, β-Catenin and p63, key to the maintenance of hair growth capital (ex vivo)
• Helps preserve hair follicle against harmful UV damage, evidenced by the lower expression of p53 markers (ex vivo)
• Improved appearance of hair length (ex vivo)