Biopharmaceutical Silicone Solutions

Momentive performance silicone is a widely used material in the biopharmaceutical industry due to its unique properties, such as biocompatibility, chemical inertness, and thermal stability. Here are some of the ways silicone is used in biopharma:

Momentive Liquid Silicone Rubber  (LSR)

 

Momentive liquid silicone rubber (LSR) is a commonly used material in the medical industry due to its biocompatibility, chemical resistance, and durability. 
 

One of the key advantages of Momentive LSR in biopharmaceutical applications is its ability to be molded into complex shapes with high precision, making it ideal for devices where accuracy and consistency are important and allowing for complex systems to be easily bent and manipulated to route fluid through a variety of devices. Furthermore, Momentive performance LSR offers self-lubricating and self-bonding advantages that aid in reducing assembly steps, and reduce friction for a higher-slip surface while meeting complex health-care healthcare-device designs.  
 

• Biocompatible: USP Class VI and ISO 10993 (parts 5, 6, 10, 11) compliant 

• Low extractables  

• Maintains physicals properties at low temperatures 

• Self-bonding properties to thermoplastics 

• No Primer required 

• Outstanding aging stability  

• Improved productivity for multi-component molding processes by eliminating the need for assembling 
   

Momentive  High Consistency Rubber (HCR)

 

Momentive High Consistency Rrubber (HCR) is a material that is often used in the biopharmaceutical industry due to its unique combination of properties that make it well-suited for a range of applications. Momentive performance high consistency rubber silicone can  be used in the molding of medical tubing to transfer living cells and fluids between different parts of the bioprocessing production process,.  and sSilicone ensures that the process is sterile and free from contamination. 

 

Effects of Sterilization

 

Momentive performance silicone offers high thermal stability, making it an excellent product for biopharmaceutical and healthcare applications requiring sterilization by steam autoclave, Eethylene oxide (EtO), or gamma radiation. The graphs below show the performance of the silicone rubber post-sterilization.  

Sterilization Resistance 

Momentive performance materials offer the strength of a silicon-oxygen backbone which offers high stability when various sterilization resistance is required. Because of their inherent chemical properties, silicone elastomers are excellent materials for biopharmaceutical and medical applications that require not only sterilization but even repeat sterilization processes. The charts below depict the performance of various Momentive silicone products against exposure to various sterilization tactics. 
 

Conditions
EtO concentration				600 mg/L		Chamber temperature	54.4ºC
EtO pressure				26.6 psia		Exposure time	2 h
Pre-humidification time at 60% RH				30 min		Post vacuum	1.45 psia
Pre-vacuum				1.5 psia		Air washes	3

Summary

 

Talk to one of our technical specialists today about which Momentive grade would work best for your biopharmaceutical applications.