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SYLOID® 244 FP
SYLOID® 244 FP is a unique synthetic silica excipient containing an amorphous silicon dioxide, chemically prepared by GRACE. Formulated with a high pore volume of 1.5 ml/g and a large internal surface area, SYLOID® 244 FP is suitable for a range of applications in pharmaceuticals and nutraceuticals.
- Manufacturer: Grace
- Product Line: SYLOID® Silicas
- Product: SYLOID® Silica Excipients
- Industries: Food & Beverage | Pharmaceuticals
- Authorized Countries: Canada | United States
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Overview
SYLOID® 244 FP is a high-pore volume silica excipient that provides multifunctional benefits and functionality across industries. Its outstanding porosity, absorption, density, particle size distribution, and internal surface area, ensure optimal performance, reducing the number of excipients needed and minimizing the complexity of formulations with maximum dosage efficacy. In pharmaceuticals and personal care, it provides excellent moisture protection and anti-tacking properties for glidant functionality and can be used as a suspension aid in tablet coating formulations. Its exceptional compatibility with active ingredients ensures versatile formulating capabilities as a glidant, tableting aid, and carrier, SYLOID® 244 FP can absorb up to 1.6 mL of liquid per gram with a strong affinity for moisture and organic base liquids.
Specifications
Appearance: Powder
Color: White
Loss on ignition (1832°F): 8.5% max.
Loss on drying (145°C): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
Iron (Fe₂O₃): 200 ppm max.
pH (5% slurry): 5.0─8.0
pH – EP (5%): 4.0─7.0
Average particle size malvern® Mastersizer® 2000: 5─7 µm
Oil adsorption: 300 g/100g
Pore volume (N₂): 1.5 ml/g
Sodium oxide (Na₂O) ≤0.2 wt. %
Sodium sulfate (Na₂SO₄): ≤1.5 wt. %
Aluminum oxide (Al₂O₃): 0.2 wt. % max.
Calcium oxide (CaO): 0.14 wt. % max.
Chlorides (Cl): 0.1 wt. % max.
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
Amorphous silicon dioxide
Multifunctional excipient
Free-flow additive
High purity
Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
Moisture protection
Reduces electrostatic charging
Improves flow properties
Moisture-assisted dry granulation
Excellent compatibility with actives
Oil absorption properties in lipid-based technologies
Prevents valve blockage in direct compression
Highly defined pore structures
Excellent porosity and particle size distribution
Enhanced moisture protection
Anti-sticking and anti-tacking
Absorbs up to 1.5 ml of liquid per gram
Matting agent
Anti-caking
Prevents clumping
Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs
Nutraceutical extracts
Film coatings
Sublingual and effervescent tablets
Related Categories
Food & Beverage
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