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- Manufacturer: Grace
- Product Line: SYLOID® Silicas
- Product: SYLOID® Silica Excipients
- Industries: Food & Beverage | Pharmaceuticals
- Authorized Countries: Canada | United States
SYLOID® 72 FP
SYLOID® 72 FP is an advanced mesoporous silicon dioxide (CAS no. 7631-86-9) formulated by GRACE to provide a moderate pore volume, large internal surface area, and bulk density of 0.16 g/cc. It acts as a high-performance excipient with multiple application possibilities in the pharmaceutical and nutraceutical industries.
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Specifications
Appearance: Powder
Color: White
Loss on ignition (1832°F): 8.5% max.
Loss on drying (150°C): 4.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (5% slurry): 6.0─8.0
Average particle size malvern® Mastersizer®: 4.6─6.7 µm max.
Wet Screen through 325 Mesh (U.S. Standard): 99.95% min.
Apparent Bulk Density: 0.11 g/cc
Compacted Bulk Density: 0.16 g/cc
Chlorides (Cl): 0.1 wt. % max.
Mercury (Hg): ≤0.1 ppm
Iron Oxide (Fe₂O₃): ≤200 ppm max.
Aluminum oxide (Al₂O₃): ≤0.2 wt. % max.
Sodium oxide (Na₂O) ≤0.2 wt. %
Calcium Oxide (CaO): ≤0.14 wt. % max.
Arsenic (As): ≤0.5 ppm
Lead (Pb): ≤0.5 ppm
Sodium sulfate (Na₂SO₄): ≤1.5 wt. %
Heavy metals: ≤20 ppm
Total aerobic plate count: ≤500 cfu/g
CAS no. 7631-86-9
Primary Chemistry:
Amorphous silicon dioxide
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Canada
United States
Overview
SYLOID® 72 FP is a high-purity synthetic silica excipient with a moderate pore volume, renowned for its advanced performance and functionality in pharmaceutical, nutraceutical, and personal care applications. With an average particle size of 4.6─6.7 µm and a large surface area, this material offers excellent adsorption of up to 1.1 ml of liquid per gram and moisture protection properties with an affinity for organic-based liquids, controlling moisture transfer in humidity-sensitive applications and preventing reactions that negatively impact drugs or decrease shelf life. It is primarily used as a glidant and tableting aid in pharmaceuticals, as a carrier and rheology modifier for liquid products.
Features & Benefits
- Amorphous silicon dioxide
- Multifunctional excipient
- Free-flow additive
- High purity
- Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
- Moisture protection
- Reduces electrostatic charging
- Improves flow properties
- Moisture-assisted dry granulation
- Excellent compatibility with actives
- Oil absorption properties in lipid-based technologies
- Prevents valve blockage in direct compression
- Highly defined pore structures
- Excellent porosity and particle size distribution
- Enhanced moisture protection
- Anti-sticking and anti-tacking
- Absorbs up to 1.5 ml of liquid per gram
- Matting agent
- Anti-caking
- Prevents clumping
- Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs
Pharmaceutical products
Nutraceutical extracts
Film coatings
Sublingual and effervescent tablets
Related Categories
Food & Beverage
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