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SYLOID® 72 FP
SYLOID® 72 FP is an advanced mesoporous silicon dioxide (CAS no. 7631-86-9) formulated by GRACE to provide a moderate pore volume, large internal surface area, and bulk density of 0.16 g/cc. It acts as a high-performance excipient with multiple application possibilities in the pharmaceutical and nutraceutical industries.
SYLOID® 72 FP is a high-purity synthetic silica excipient with a moderate pore volume, renowned for its advanced performance and functionality in pharmaceutical, nutraceutical, and personal care applications. With an average particle size of 4.6─6.7 µm and a large surface area, this material offers excellent adsorption of up to 1.1 ml of liquid per gram and moisture protection properties with an affinity for organic-based liquids, controlling moisture transfer in humidity-sensitive applications and preventing reactions that negatively impact drugs or decrease shelf life. It is primarily used as a glidant and tableting aid in pharmaceuticals, as a carrier and rheology modifier for liquid products.
Specifications
Appearance: Powder Color: White Loss on ignition (1832°F): 8.5% max. Loss on drying (150°C): 4.0% max. SiO₂ content (dry basis): 99.0% min Sulfate (SO₄): 0.5% max pH (5% slurry): 6.0─8.0 Average particle size malvern® Mastersizer®: 4.6─6.7 µm max. Wet Screen through 325 Mesh (U.S. Standard): 99.95% min. Apparent Bulk Density: 0.11 g/cc Compacted Bulk Density: 0.16 g/cc Chlorides (Cl): 0.1 wt. % max. Mercury (Hg): ≤0.1 ppm Iron Oxide (Fe₂O₃): ≤200 ppm max. Aluminum oxide (Al₂O₃): ≤0.2 wt. % max. Sodium oxide (Na₂O) ≤0.2 wt. % Calcium Oxide (CaO): ≤0.14 wt. % max. Arsenic (As): ≤0.5 ppm Lead (Pb): ≤0.5 ppm Sodium sulfate (Na₂SO₄): ≤1.5 wt. % Heavy metals: ≤20 ppm Total aerobic plate count: ≤500 cfu/g CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
Amorphous silicon dioxide Multifunctional excipient Free-flow additive High purity Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability Moisture protection Reduces electrostatic charging Improves flow properties Moisture-assisted dry granulation Excellent compatibility with actives Oil absorption properties in lipid-based technologies Prevents valve blockage in direct compression Highly defined pore structures Excellent porosity and particle size distribution Enhanced moisture protection Anti-sticking and anti-tacking Absorbs up to 1.5 ml of liquid per gram Matting agent Anti-caking Prevents clumping Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs Pharmaceutical products Nutraceutical extracts Film coatings Sublingual and effervescent tablets
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