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SYLOID® XDP 3050
SYLOID® XDP 3050 is a high-performance silicon dioxide-based excipient agent used in the formulation of pharmaceuticals and nutraceuticals. Its controlled particle size and high porosity makes it the ideal carrier for lipids.
- Manufacturer: Grace
- Product Line: SYLOID® Silicas
- Product: SYLOID® Silica Excipients
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Overview
SYLOID® XDP 3050 is a synthetic amorphous silica containing a high-purity silicon dioxide with superior stability. Specially engineered to be a high-performance lipid carrier with excellent absorption properties, SYLOID® XDP 3050 effectively transforms liquids, such as oily actives and lipid-based systems, to free-flowing solids and allows nutraceutical formulators to achieve solid dosage forms with liquid ingredients. Its specific pore size and bulk density of 275 g/l ensure optimal drug load or lipid delivery in a given volume for table or capsule pharmaceuticals.
Specifications
Appearance: Powder
Color: White
Loss on ignition (USP, 1000°F, 1 h): 8.5% max.
Loss on drying (USP, 145°C, 4 h): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (USP, 5 % aqueous suspension): 4.0─8.0
pH (EP): 4.0─7.0
Average particle size malvern® Mastersizer®: 48─66 µm
Specific Surface Area (BET): 320 m²/g
Oil absorption (linseed oil): 300 g/100 g
Tapped bulk density: 275 g/l
Chlorides (Cl) dry basis, USP: 0.1 % max.
Mercury (Hg): 0.1 mg/kg max.
Iron Oxide (Fe₂O₃) dry basis: 0.03% max.
Sodium oxide (Na₂O) dry basis 0.15% max
Calcium Oxide (CaO): 0.14 % max.
Water Absorption (EP): yes
Substances soluble in HCl (EP): 10.0 mg max.
Arsenic (As): 0.5 mg/kg max.
Cadmium (Cd): 0.5 mg/kg max.
Lead (Pb): 1.0 mg/kg max.
Total aerobic plate count: 1000 cfu/g
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
Amorphous silicon dioxide
Multifunctional excipient
Maximum load capacity
Excellent release and bioavailability
Free-flow additive
High purity
Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
Moisture protection
Reduces electrostatic charging
Improves flow properties
Moisture-assisted dry granulation
Excellent compatibility with actives
Oil absorption properties in lipid-based technologies
Prevents valve blockage in direct compression
Highly defined pore structures
Excellent porosity and particle size distribution
Enhanced moisture protection
Anti-sticking and anti-tacking
Absorbs up to 1.5 ml of liquid per gram
Matting agent
Anti-caking
Prevents clumping
Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs
Pharmacuetical products
Nutraceutical extracts
Film coatings
Sublingual and effervescent tablets
Liquisolid pharmaceuticals
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