SYLOID® XDP 3050

SYLOID® XDP 3050 is a high-performance silicon dioxide-based excipient agent used in the formulation of pharmaceuticals and nutraceuticals. Its controlled particle size and high porosity makes it the ideal carrier for lipids.

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Specifications

Appearance: Powder
Color: White
Loss on ignition (USP, 1000°F, 1 h): 8.5% max.
Loss on drying (USP, 145°C, 4 h): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (USP, 5 % aqueous suspension): 4.0─8.0
pH (EP): 4.0─7.0
Average particle size malvern® Mastersizer®: 48─66 µm
Specific Surface Area (BET): 320 m²/g
Oil absorption (linseed oil): 300 g/100 g
Tapped bulk density: 275 g/l
Chlorides (Cl) dry basis, USP: 0.1 % max.
Mercury (Hg): 0.1 mg/kg max.
Iron Oxide (Fe₂O₃) dry basis: 0.03% max.
Sodium oxide (Na₂O) dry basis 0.15% max
Calcium Oxide (CaO): 0.14 % max.
Water Absorption (EP): yes
Substances soluble in HCl (EP): 10.0 mg max.
Arsenic (As): 0.5 mg/kg max.
Cadmium (Cd): 0.5 mg/kg max.
Lead (Pb): 1.0 mg/kg max.
Total aerobic plate count: 1000 cfu/g
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide

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Manufacturer
Grace
Product Line
SYLOID® Silicas
Product
SYLOID® Silica Excipients
Industries
Pharmaceuticals
Authorized Countries
Canada United States
supplier logo

Specifications

Appearance: Powder
Color: White
Loss on ignition (USP, 1000°F, 1 h): 8.5% max.
Loss on drying (USP, 145°C, 4 h): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (USP, 5 % aqueous suspension): 4.0─8.0
pH (EP): 4.0─7.0
Average particle size malvern® Mastersizer®: 48─66 µm
Specific Surface Area (BET): 320 m²/g
Oil absorption (linseed oil): 300 g/100 g
Tapped bulk density: 275 g/l
Chlorides (Cl) dry basis, USP: 0.1 % max.
Mercury (Hg): 0.1 mg/kg max.
Iron Oxide (Fe₂O₃) dry basis: 0.03% max.
Sodium oxide (Na₂O) dry basis 0.15% max
Calcium Oxide (CaO): 0.14 % max.
Water Absorption (EP): yes
Substances soluble in HCl (EP): 10.0 mg max.
Arsenic (As): 0.5 mg/kg max.
Cadmium (Cd): 0.5 mg/kg max.
Lead (Pb): 1.0 mg/kg max.
Total aerobic plate count: 1000 cfu/g
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide

Features & Benefits

  • Amorphous silicon dioxide
  • Multifunctional excipient
  • Maximum load capacity
  • Excellent release and bioavailability
  • Free-flow additive
  • High purity
  • Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
  • Moisture protection
  • Reduces electrostatic charging
  • Improves flow properties
  • Moisture-assisted dry granulation
  • Excellent compatibility with actives
  • Oil absorption properties in lipid-based technologies
  • Prevents valve blockage in direct compression
  • Highly defined pore structures
  • Excellent porosity and particle size distribution
  • Enhanced moisture protection
  • Anti-sticking and anti-tacking
  • Absorbs up to 1.5 ml of liquid per gram
  • Matting agent
  • Anti-caking
  • Prevents clumping
  • Viscosity control

Problems Solved

Valve blockage in direct compression applications

Applications

APIs
Pharmacuetical products
Nutraceutical extracts
Film coatings
Sublingual and effervescent tablets
Liquisolid pharmaceuticals

Related Applications
Pharmaceuticals
Related Functions
Pharmaceuticals

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