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Methyl magnesium chloride (MeMgCl) is an organomagnesium compound widely used as a fundamental component for synthesis in a broad spectrum of applications.
Methyl magnesium chloride, also referred to as a Grignard reagent, plays a vital role in nucleophilic substitutions and acts as a potent base, particularly when combined with an amine. Methyl magnesium chloride exhibits a decreased reactivity compared to bromide, enabling the use of gentler reaction conditions, particularly in the presence of competing bases.
Form: Liquid
Color: Translucent
CAS number: 676-58-4
EINECS number: 211-629-7
Formula: CH3ClMg
Titer (moles/kg solution): 3.0
Molecular weight: 74.8
Weight percent active: 21–22
Reactivity: Water/oxygen reactive
Specific gravity at 25°C: 1.01
Flash point (THF) (tag closed cup): −17°C (1.4°F)
Autoignition temperature (THF): 321°C (610°F)
Solvent: Tetrahydrofuran (THF)
Primary Chemistry: Methyl magnesium chloride
Strong nucleophile
Reactivity enables a wide range of chemical transformations
Versatile carbon–carbon bond formation
High reactivity and selectivity
Compatible with various solvents
Synthesis of alcohols
Lack of compatibility with solvents
Chemical intermediate manufacturing
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