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Fujicalin®
Fujicalin® made of Dibasic Calcium Phosphate Anhydrous (DCPA) is a direct compression excipient. Fuji's highly specialized and proprietary manufacturing process that yields a unique primary particle is the key to Fujicalin®'s superior performance.
- Manufacturer: Fuji Chemical Industries USA, Inc
- Product Line: Fujicalin®
- Product: Fujicalin® Excipient
- Industries: Food & Beverage | Pharmaceuticals
- Authorized Countries: United States
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Overview
CAS # 7757-93-9
Fujicalin® is a Dibasic Calcium Phosphate Anhydrous (DCPA) designed to function as a direct compression excipient. It has exceptional flow and compression characteristics while sustaining the ability for rapid disintegration. The key to Fujicalin®’s superior performance is the highly specialized and proprietary manufacturing process that yields unique primary particles. Spherically granulated Fujicalin®, has lower mean particle size and extremely high specific surface area when compared to other available Dibasic Calcium Phosphate Anhydrous (DCPA) and Dibasic Calcium Phosphate Dihydrate (DCPD).
Fujicalin®’s patented manufacturing process yields porous spheres with high specific surface area. Fujicalin® is ideally suited for direct compression formulations especially involving difficult-to compress materials like oily actives. It can be used to reduce tablet weight variation and improve content uniformity. Fujicalin®’s density will facilitate the design of smaller tablets.
Specifications
Appearance: White crystalline powder
Average particle size (μm): 120
Carr value: 86.5
BET surface area (m2/g): 40
Compressibility index: 15.1
Loose bulk density (g/ml): 0.46
Tapped bulk density (g/ml): 0.54
Mean particle size distribution (μm): 121
Angle of repose (°): 30
Loss on drying (%), 110ºC/7hrs: ≦ 1.0
Oil adsorbing capacity (ml/g): 1.1
Water adsorbing capacity (ml/g): 1.2
Water activity: 0.11
Ingredient: Anhydrous Dibasic Calcium Phosphate (USP) Calcium Hydrogen Phosphate, Anhydrous (EP)
Chemical formula: CaHPO4
Features & Benefits
- Highly compressible, and produces harder tablets than other directly compressible conventional excipients
- Easy blending and excellent flowing properties due to its spherical shape, which creates less friction
- Works with other disintegrants to promote rapid disintegration regardless of tablet hardness
- Fujicalin® granules have a smooth surface and are less abrasive compared to other DCPAs and DCPDs
- High degree of porosity is retained even under high pressure, resulting in excellent oil adsorbing capability
- Fujicalin® facilitates the production of easily disintegrating, smaller and thinner tablets
- Fujicalin®'s smooth and spherical granules are less abrasive on tableting machines leading to trouble free operations.
Applications
Dibasic calcium phosphate anhydrous is widely used in oral pharmaceutical products and food products. Fujicalin® is recommended for preparing probiotics formulation.
With Fujicalin®, probiotics tablets can be produced by direct compression at low compression forces which leads to increasing cell viability. Commercially available probiotic products of Fujicalin® can be stored at room temperature with shelf life up to 3 years using normal bottle packaging. Approved for pharmaceutical and food excipient.
Fujicalin® is an ideal carrier for Self-Emulsifying Drug Delivery System (SEDDS), liquisolid system, as well as Hot Melt Extrusion (HME) to improve tablet properties and bioavailability of poorly water soluble drugs. Fujicalin® has also been commercially used as primary excipient in roller compaction. Fujicalin® is able to facilitate fast disintegration of tablets and is recommended for fast releasing SEDDS applications.
Fujicalin®'s anhydrous nature results in very low water of crystallization thus making it the ideal choice for hydrolysable drugs.
Fujicalin® conforms to USP, EP, and JP.
Anhydrous dibasic calcium phosphate or calcium hydrogen phosphate, Anhydrous is also applicable for food use. US DMF Type IV filed.
Listed as GRAS (Generally Recognized As Safe).
Related Applications
Pharmaceuticals
Related Brands
Pharmaceuticals
Related Categories
Food & Beverage
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