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SYLOID® 63 FP
SYLOID® 63 FP is a white, free-flowing silica powder from GRACE designed with a low pore volume of 0.4 ml/g and a large internal surface area. It is recommended as a free-flow and tableting additive for humidity-sensitive pharmaceutical formulations.
SYLOID® 63 FP is a unique mesoporous silica excipient consisting of a chemically prepared, synthetic amorphous silicon dioxide (CAS no. 7631-86-9). Its highly defined pore structure has a low pore volume of 0.4 ml/g with a density of 0.41 g/cc, allowing for excellent adsorption, particle size distribution, and internal surface area and creating less dust for easier GMP compliance and more compact storage. It also helps to minimize the number of excipients required in pharmaceutical formulations and improves the effectiveness of products. SYLOID® 63 FP is especially recommended as a free-flow and tableting additive, providing exceptional compatibility with active ingredients. Its excellent moisture protection properties ensure silicas control moisture transfer in humidity-sensitive applications, preventing reactions that negatively impact drugs or decrease shelf life.
Specifications
Appearance: Powder Color: White Loss on ignition (1832°F): 8.5% max. Loss on drying (145°C): 4.0% max. SiO₂ content (dry basis): 99.0% min Sulfate (SO₄): 0.5% max pH (5% slurry): 4.0─6.0 Oil adsorption: 80 g/100g Pore volume (H₂O): 0.4 ml/g Apparent Bulk Density: 0.29 g/cc Compacted Bulk Density: 0.41 g/cc Chlorides (Cl): ≤0.1 wt. % max. Mercury (Hg): ≤0.1 ppm Iron (Fe₂O₃): 200 ppm max. Aluminum oxide (Al₂O₃): ≤0.2 wt. % max. Sodium oxide (Na₂O) ≤0.2 wt. % Calcium Oxide (CaO): ≤0.14 wt. % max. Arsenic (As): ≤0.5 ppm Lead (Pb): ≤0.5 ppm Cadmium (Cd): ≤0.5 ppm Sodium sulfate (Na₂SO₄): ≤1.5 wt. % Heavy metals: ≤20 ppm Total aerobic plate count: ≤500 cfu/g CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
Amorphous silicon dioxide Multifunctional excipient Free-flow additive High purity Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability Moisture protection Reduces electrostatic charging Improves flow properties Moisture-assisted dry granulation Excellent compatibility with activity Oil absorption properties in lipid-based technologies Prevents valve blockage in direct compression Highly defined pore structures Excellent porosity and particle size distribution Enhanced moisture protection Anti-sticking and anti-tacking Absorbs up to 1.5 ml of liquid per gram Matting agent Anti-caking Prevents clumping Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs Pharmaceutical products Nutraceutical extracts Film coatings Sublingual and effervescent tablets
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