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SYLOID® XDP 3150
SYLOID® XDP 3150 is a high-purity silica powder that provides superior adsorptive power of 1 to 1.5 times its weight in liquids while remaining a free-flowing, non-dusty material for pharmaceutical and nutraceutical applications. It helps to enhance the bioavailability and API loading in solid dosage forms and is especially useful for creating stable liquisolid formulations.
Documents
- Manufacturer: Grace
- Product Line: SYLOID® Silicas
- Product: SYLOID® Silica Excipients
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Manufacturer
Product Line
Product
Industries
Authorized Countries
Canada
United States
Overview
SYLOID® XDP 3150 silica is an advanced porous carrier capable of absorbing up to 1 to 1.5 times its weight in liquids. It is designed with a high pore volume and large internal surface area for efficient liquid absorption in pharmaceutical and nutraceutical applications. ts high purity silica gel provides superior stability and excellent compatibility with active ingredients, while the narrow particle size distribution improves consistency and uniformity in formulations. As a synthetic amorphous silica in a high-purity white powder form, SYLOID® XDP 3150 is designed to transform liquids, particularly oily actives, and lipid-based systems, into stable, free-flowing solids, allowing for the convenient formulation of liquisolids, solid dispersions, semi-solids, and self-emulsifying drug delivery systems (SEDDS). Additionally, it ensures improved release of APIs from solid dosage forms without compromising quality.
Specifications
Appearance: Powder
Color: White
Loss on ignition (USP, 1000°F, 1 h): 8.5% max.
Loss on drying (USP, 145°C, 4 h): 5.0% max.
SiO₂ content (dry basis): 99.0% min
Sulfate (SO₄): 0.5% max
pH (USP, 5 % aqueous suspension): 4.0─8.0
pH (EP): 4.0─7.0
Average particle size malvern® Mastersizer®: 120─170 µm
Specific Surface Area (BET): 320 m²/g
Oil absorption (linseed oil): 300 g/100 g
Tapped bulk density: 275 g/l
Chlorides (Cl) dry basis, USP: 0.1 % max.
Mercury (Hg): 0.1 mg/kg max.
Iron Oxide (Fe₂O₃) dry basis: 0.03% max.
Sodium oxide (Na₂O) dry basis 0.15% max
Calcium Oxide (CaO): 0.14 % max.
Water Absorption (EP): yes
Substances soluble in HCl (EP): 10.0 mg max.
Arsenic (As): 0.5 mg/kg max.
Cadmium (Cd): 0.5 mg/kg max.
Lead (Pb): 1.0 mg/kg max.
Total aerobic plate count: 1000 cfu/g
CAS no. 7631-86-9
Primary Chemistry: Amorphous silicon dioxide
Features & Benefits
- Amorphous silicon dioxide
- Multifunctional excipient
- Maximum load capacity
- Excellent release and bioavailability
- Free-flow additive
- High purity
- Improve manufacturing efficiency, dissolution, therapeutic effectiveness, and stability
- Moisture protection
- Reduces electrostatic charging
- Improves flow properties
- Moisture-assisted dry granulation
- Excellent compatibility with actives
- Oil absorption properties in lipid-based technologies
- Prevents valve blockage in direct compression
- Highly defined pore structures
- Excellent porosity and particle size distribution
- Enhanced moisture protection
- Anti-sticking and anti-tacking
- Absorbs up to 1.5 ml of liquid per gram
- Matting agent
- Anti-caking
- Prevents clumping
- Viscosity control
Problems Solved
Valve blockage in direct compression applications
Applications
APIs Pharmacuetical products Nutraceutical extracts Film coatings Sublingual and effervescent tablets Liquisolid pharmaceuticals
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