Neusilin® S1 is an alkaline, synthetic magnesium aluminometasilicate with high water content. It has exceptional excipient properties including its use as a diluent, binder, and disintegration aid in oral solid-dosage form pharmaceuticals.
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CAS # 12511-31-8
Neusilin® is a multifunctional excipient that can be used in both direct compression and wet granulation of solid dosage forms. Neusilin® improves the quality of tablets, powder, granules and capsules. Unlike other magnesium aluminum silicates, it does not develop gel with aqueous solutions.
Appearance: White granules
Degree of whiteness: > 95%
Physical form: Amorphous
True specific gravity: 2.0
Solubility: Practically insoluble in water and ethanol
Composition on dried basis:
Al2O3: 29.1% - 35.5%
MgO: 11.4% - 14.0%
SiO2: 29.2% - 35.6%
Loss on drying (110°C, 7 hours): 13% - 20%
Loose bulk density (g/mL): 0.30 - 0.37
Tapped bulk density (g/mL): 0.36 - 0.43
Specific surface area: 110 m²/g
Average particle size: 112 μm
Angle of repose: 30°
Oil adsorbing capacity: 1.3 mL/g
Water adsorbing capacity: 1.0 mL/g
Acid consuming capacity: ≥ 210 mL/g
pH (4% slurry): 8.5 - 10.0
EINECS number: 235-682-0
Chemical formula: Al2O3·MgO·1.7SiO2·xH2O
Superior compressibility; hard tablets can be made at low compression force
Binds and improves hardness of other fillers and binders at low concentration
Acts as a diluent in solid dosage forms
Aids in tablet disintegration
Very large specific surface area
High oil and water adsorption capacity
Heat stable
Long shelf life (3 years)
Meets all the requirements of the current USP/NF and JPC
Neusilin® S1 is typically used as a diluent in solid dosage forms as well as a binder, disintegration aid, and increases hardness in tablets.
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