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Neusilin® S1
Neusilin® S1 is an alkaline, synthetic magnesium aluminometasilicate with high water content. It has exceptional excipient properties including its use as a diluent, binder, and disintegration aid in oral solid-dosage form pharmaceuticals.
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- Manufacturer: Fuji Chemical Industries USA, Inc
- Product Line: Neusilin®
- Product: Neusilin® Alkaline Grades
- Industries: Food & Beverage | Pharmaceuticals
- Authorized Countries: United States
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Manufacturer
Product Line
Product
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Authorized Countries
United States
Overview
CAS # 12511-31-8
Neusilin® is a multifunctional excipient that can be used in both direct compression and wet granulation of solid dosage forms. Neusilin® improves the quality of tablets, powder, granules and capsules. Unlike other magnesium aluminum silicates, it does not develop gel with aqueous solutions.
Specifications
Appearance: White granules
Degree of whiteness: > 95%
Physical form: Amorphous
True specific gravity: 2.0
Solubility: Practically insoluble in water and ethanol
Composition on dried basis:
Al2O3: 29.1% - 35.5%
MgO: 11.4% - 14.0%
SiO2: 29.2% - 35.6%
Loss on drying (110°C, 7 hours): 13% - 20%
Loose bulk density (g/mL): 0.30 - 0.37
Tapped bulk density (g/mL): 0.36 - 0.43
Specific surface area: 110 m²/g
Average particle size: 112 μm
Angle of repose: 30°
Oil adsorbing capacity: 1.3 mL/g
Water adsorbing capacity: 1.0 mL/g
Acid consuming capacity: ≥ 210 mL/g
pH (4% slurry): 8.5 - 10.0
EINECS number: 235-682-0
Chemical formula: Al2O3·MgO·1.7SiO2·xH2O
Features & Benefits
- Superior compressibility; hard tablets can be made at low compression force
- Binds and improves hardness of other fillers and binders at low concentration
- Acts as a diluent in solid dosage forms
- Aids in tablet disintegration
- Very large specific surface area
- High oil and water adsorption capacity
- Heat stable
- Long shelf life (3 years)
- Meets all the requirements of the current USP/NF and JPC
Applications
Neusilin® S1 is typically used as a diluent in solid dosage forms as well as a binder, disintegration aid, and increases hardness in tablets.
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