Neusilin® UFL2 is a pH-neutral, low-water multifunctional excipient. It improves API delivery in pharmaceuticals and provides mattifying properties in cosmetics.
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CAS # 12511-31-8
Neusilin® is has been used in hundreds of pharmaceutical preparations for over 60 years. Neusilin® UFL2 is a well-accepted, multifunctional excipient with excellent adsorption capacity. It can maintain its powdery state while adsorbing up to 330% of its own weight, due to its extremely large specific surface area and porous reticulate structure.
In deodorants, Neusilin® UFL2 can both neutralize and absorb odors. For cosmetics and skin care products, it provides great absorption of sebum, oil, and water. It also aids in pigment dispersion and imparts anti-caking and opacifying benefits.
Appearance: White powder
Degree of whiteness: > 95%
Physical form: Amorphous
True specific gravity: 2.2
Solubility: Practically insoluble in water and ethanol
Composition on dried basis:
Al2O3: 29.1% - 35.5%
MgO: 11.4% - 14.0%
SiO2: 29.2% - 35.6%
Loss on drying (110°C, 7 hours): < 7%
Loose bulk density (g/mL): 0.06 - 0.11
Tapped bulk density (g/mL): 0.10 - 0.17
Specific surface area (m²/g): 300
Average particle size (μm): 3.1
Angle of repose: 45°
Oil adsorbing capacity (mL/g): 2.7 - 3.4
Water adsorbing capacity (mL/g): 2.4 - 3.1
Acid consuming capacity (mL/g): ≥ 210
pH (4% slurry): 6.0 - 8.0
EINECS number: 235-682-0
Chemical formula: Al2O3·MgO·1.7SiO2·xH2O
Superior compressibility; hard tablets can be made at low compression force
Improves hardness of other fillers and binders at low concentration
Helps stabilize moisture-sensitive and lipophilic APIs
Excellent carrier for solid dispersion via self-micro emulsifying drug delivery system (SMEDDS) and hot-melt extrusion
Increases hardness in tablets
Aids in tablet disintegration
Increases flowability
Functions as an anti-caking agent even in high humidity conditions
Solidifies liquid APIs
Very large specific surface area
High oil and water adsorption capacity
Excellent sebum absorption capability
Deodorant properties
Aids in pigment dispersion
Imparts opacifying properties
Higher API load
Restricts reversion of amorphous form to crystalline state
Inert core material
Heat stable
Long shelf life (3 years)
Meets all the requirements of the current USP/NF and JPC
Neusilin® UFL2 can be used as an excipient in a variety of applications. It can be used as a diluent in solid dosage forms, and for tablets, it can bind, increase hardness, and aid in disintegration. It functions as a stabilizer in deliquescent drugs, and solidifies liquid APIs when its necessary to convert them from an oil to a powder, for example. Neusilin® UFL2 can also be used in suspensions. Due to its adsorption capacity, it is ideal for oily skin and acne treatment products, deodorant, lotion, pressed powders, and cleansers.
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