Neusilin® S2 is an alkaline, synthetic magnesium aluminometasilicate with multifunctional excipient properties. It has low water content and can be used in oral solid-dosage form pharmaceuticals to bind, increase hardness, and aid in tablet disintegration.
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CAS # 12511-31-8
Neusilin® is a well-accepted multifunctional excipient. Neusilin® S2 can be used to formulate antibiotics, herbal mixtures, vitamins, and more. Working in both direct compression and wet granulation, it improves the quality of tablets, powder, granules and capsules, and it does not develop gel with aqueous solutions.
Appearance: White granules
Degree of whiteness: > 95%
Physical form: Amorphous
True specific gravity: 2.2
Solubility: Practically insoluble in water and ethanol
Composition on dried basis:
Al2O3: 29.1% - 35.5%
MgO: 11.4% - 14.0%
SiO2: 29.2% - 35.6%
Loss on drying (110°C, 7 hours): < 5%
Loose bulk density (g/mL): 0.29 - 0.37
Tapped bulk density (g/mL): 0.34 - 0.42
Specific surface area (m²/g): 110
Average particle size (μm): 115
Angle of repose: 30°
Oil adsorbing capacity (mL/g): 1.4
Water adsorbing capacity (mL/g): 1.2
Acid consuming capacity (mL/g): ≥ 210
pH (4% slurry): 8.5 - 10.0
EINECS number: 235-682-0
Chemical formula: Al2O3·MgO·1.7SiO2·xH2O
Superior compressibility; hard tablets can be made at low compression force
Binds and improves hardness of other fillers and binders at low concentration
Acts as a diluent in solid dosage forms
Aids in tablet disintegration
Very large specific surface area
High oil and water adsorption capacity
Heat stable
Long shelf life (3 years)
Meets all the requirements of the current USP/NF and JPC
Neusilin® S2 is typically used as a diluent in solid dosage forms as well as a binder, disintegration aid, and increases hardness in tablets.
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