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LACTEL® 50:50 DL-PLGE, IV 0.55-0.75
LACTEL® 50:50 DL-PLGE, IV 0.55-0.75 is a non-GMO pharmaceutical excipient with a polymer composition of 50 mol % D,L-lactide and 50 mol % Glycolide with an ester end group and no added preservatives. It is formulated by Evonik as a white to tan pelletized solid with an inherent viscosity of 0.55─0.75 dL/g in HFIP and a degradation time of 3 months max.
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- Manufacturer: Evonik Corporation
- Product Line: LACTEL® Polymers
- Product: LACTEL® PLGE Polymers
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Canada
United States
Overview
LACTEL® 50:50 DL-PLGE, IV 0.55-0.75 is a 100% bioresorbable PLGA-based copolymer containing a 50:50 mol ratio of D,L-Lactide and Glycolide, providing a uniform degredation rate of 3 months for controlled drug delivery. It is compatible with a range of pharmaceutical substance types, including peptides, proteins, nanoparticles, and microparticles for the formulation of long-acting injectable formulations in veterinary medicine and human generic drug formulations. As a non-solvent purified poly (D,L-lactide-co-glycolide) polymer with an amorphous nature, it exhibits enhanced adaptability and versatility in formulations with superior stability properties. LACTEL® 50:50 DL-PLGE, IV 0.55-0.75 is non-GMO certified and has no added preservatives.
Specifications
Physical state: Solid
Form: Granules
Color: White to light tan
Inherent viscosity (IV) dL/g: 0.55─0.75 (in HFIP)
Degradation time: <3 months
Crystalline Melt Transition (°C): Amorphous
Glass transition temp (°C): 45─50
Solubility (@ 5% w/w): Dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, acetone
Approx. resorption (months): 1─2
Density (g/mL): 1.34
Tensile Strength (psi): 6000─8000
Elongation (%): 3─10
Modulus (psi): 2─4x10⁵
CAS No. 26780-50-7
Primary Chemistry: Poly(DL-lactide-co-glycolide)
Features & Benefits
- 50:50 ratio of D,L-Lactide and Glycolide
- Ester end group
- 3-month degradation time
- Biodegradable
- Ideal for terminal sterilization
- Bioabsorbable excipient
- Suitable for use with small molecules, peptides, proteins, and other substances
- Non-GMO
- No added preservatives
- Cost effective
Applications
Human generic drug formulations Long-acting injectable formulations Price sensitive applications veterinary medicine
Related Applications
Pharmaceuticals
Related Functions
Pharmaceuticals
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