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LACTEL® 50:50 DL-PLGA, IV 0.55-0.75
LACTEL® 50:50 DL-PLGA, IV 0.55-0.75 is a non-solvent purified lactide-glycolide copolymer with amorphous properties and no added preservatives for controlled release applications in pharmaceuticals. With a 50:50 mol ratio of D,L-lactide and glycolide, it exhibits an inherent viscosity of 0.55─0.75 dL/g in HFIP and a degradation period of 3 months.
Documents
- Manufacturer: Evonik Corporation
- Product Line: LACTEL® Polymers
- Product: LACTEL® PLGA Polymers
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Fulfilled By ChemPoint
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Product Line
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Authorized Countries
Canada
United States
Overview
LACTEL® 50:50 DL-PLGA, IV 0.55-0.75 is a premium lactide-based polymer containing a poly (D,L-lactide-co-glycolide) copolymer with equal mol ratios of DL-lactide and glycolide. It is recommended for its excellent performance in medical and pharmaceutical applications, such as long-acting injectable formulations in veterinary medicine and human generic drug formulations, providing controlled drug release. Its excellent biodegradability allows LACTEL® 50:50 DL-PLGA, IV 0.55-0.75 to break down into lactic acid and glycolic acids and be fully metabolized by the body for full effectiveness.
Specifications
Physical state: Solid
Form: Granules
Color: White to light tan
Inherent viscosity (IV) dL/g: 0.55─0.75 (in HFIP)
Degradation time: <3 months
Crystalline Melt Transition (°C): Amorphous
Glass transition temp (°C): 45─50
Solubility (@ 5% w/w): Dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, acetone
Approx. resorption (months): 1─2
Density (g/mL): 1.34
Tensile Strength (psi): 6000─8000
Elongation (%): 3─10
Modulus (psi): 2─4x10⁵
CAS no. 26780-50-7
Primary Chemistry:
Poly(DL-lactide-co-glycolide)
Features & Benefits
- 50:50 ratio of D,L-Lactide and Glycolide
- Acid end group
- No added preservatives
- Non-GMO
- Amorphous
- 3 month degradation period
- Bioabsorbable excipient
- Suitable for use with small molecules, peptides, proteins, and other substances
- Unpurified
- Cost-effective
- Non-GMO
Applications
Human generic drug formulations
Long-acting injectable formulations
Price sensitive applications
veterinary medicine
Related Applications
Pharmaceuticals
Related Functions
Pharmaceuticals
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