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LACTEL® 75:25 DL-PLGE, IV 0.55-0.75
LACTEL® 75:25 DL-PLGE, IV 0.55-0.75 is an unpurified bioresorbable polymer that offers a cost-effective excipient solution for controlled drug release systems in pharmaceutical and medical applications. It exhibits inherent viscosity of 0.55─0.75 dL/g in HFIP and a degradation time of 6 months maximum.
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- Manufacturer: Evonik Corporation
- Product Line: LACTEL® Polymers
- Product: LACTEL® PLGE Polymers
- Industries: Pharmaceuticals
- Authorized Countries: Canada | United States
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Canada
United States
Overview
LACTEL® 75:25 DL-PLGE, IV 0.55-0.75 is a non-GMO pharmaceutical excipient with a polymer composition of 75 mol % D,L-lactide and 25 mol % Glycolide with an ester end group and no added preservatives. Formulated with 100% bioresorbability, it is fully metabolized by the body for exceptional effectiveness allowing for controlled drug release and a degredation period of 6 months. LACTEL® 75:25 DL-PLGE, IV 0.55-0.75 should be used in the formulation of veterinary medicine and human generic drug formulations.
Specifications
Physical state: Solid
Form: Granules or pellets
Color: White to yellowish, off-white to light tan
Inherent viscosity (IV) dL/g: 0.55─0.75 (in chloroform)
Degradation time: <6 months
Crystalline Melt Transition (°C): Amorphous
Glass transition temp (°C): 50─55
Solubility (@ 5% w/w): Dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, acetone
Approx. resorption (months): 4─5
Density (g/mL): 1.30
Tensile Strength (psi): 6000─8000
Elongation (%): 3─10
Modulus (psi): 2─4x10⁵
CAS No. 26780-50-7
Primary Chemistry:
Poly(DL-lactide-co-glycolide)
Features & Benefits
- 75:25 ratio of D,L-Lactide and Glycolide
- Ester end group
- 6-month degradation time
- Biodegradable
- Ideal for terminal sterilization
- Bioabsorbable excipient
- Suitable for use with small molecules, peptides, proteins, and other substances
- Non-GMO
- No added preservatives
- Cost effective
Applications
Human generic drug formulations Long-acting injectable formulations Price sensitive applications veterinary medicine
Related Applications
Pharmaceuticals
Related Functions
Pharmaceuticals
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