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LACTEL® 85:15 DL-PLGE, IV 0.55-0.75
LACTEL® 85:15 DL-PLGE, IV 0.55-0.75 is a biodegradable poly(lactic-co-glycolide) (PLGA) copolymer made up of a 85:15 ratio of D,L-lactide and glycolide. It exhibits an inherent viscosity range of 0.55─0.75 dL/g in chloroform and a degredation period of 6 months.
LACTEL® 85:15 DL-PLGE, IV 0.55-0.75 is a versatile pellatized excipient polymer available as white to tan granules for the formulation of long-acting injectable formulations in veterinary medicine and human generic drug formulations. Manufactured using a streamlined process to produce a cost-effective PLGA copolymer, Evonik's LACTEL® 50:50 DL-PLGE, IV 0.76-0.94 is non-solvent purified and formulated with no-added preservatives. It is ideal for terminal stabilization and exhibits long term stability, making them suitable for use with small molecules, proteins, peptides, and more.
Specifications
Physical state: Solid Form: Granules or pellets Color: White to yellowish, off-white to light tan Inherent viscosity (IV) dL/g: 0.55─0.75 (in chloroform) Degradation time: <9 months Crystalline Melt Transition (°C): Amorphous Glass transition temp (°C): 50─55 Solubility (@ 5% w/w): Dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, acetone Approx. resorption (months): 5─6 Density (g/mL): 1.27 Tensile Strength (psi): 6000─8000 Elongation (%): 3─10 Modulus (psi): 2─4x10⁵ CAS No. 26780-50-7
Primary Chemistry: Poly(DL-lactide-co-glycolide)
Features & Benefits
85:15 ratio of D,L-Lactide and Glycolide Ester end group 9-month degradation time Biodegradable Ideal for terminal sterilization Bioabsorbable excipient Suitable for use with small molecules, peptides, proteins, and other substances Non-GMO No added preservatives Cost effective
Applications
Human generic drug formulations Long-acting injectable formulations Price sensitive applications veterinary medicine
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