CAB-381-20 is a mixed cellulose ester with moderate butyryl content and high viscosity. It is commonly used as a film former or an additive in solventborne coatings to improve leveling, gloss, UV resistance, and durability. CAB-381-20 is soluble in a wide range of common organic solvents and is compatible with most common resins and plasticizers. CAB-381-20 is the ideal film former for applications that require enhanced appearance and reliable performance, such as automotive coatings, wood coatings, and lacquers.

CAB-381-20 is also commonly used in nail polish, as it provides superior stability when compared to other film formers like nitrocellulose. When CAB-381-20 is used as a film former in nail polish formulations, it allows for faster drying and fewer applications than similar formulations with nitrocellulose. Compared to nitrocellulose, cellulose esters such as CAB-381-20 are safer and easier to handle because of their low flammability risk. In addition, cost savings can be realized by using CAB-381-20 in nail polish, as the same durability seen with a lower–molecular weight polymer can be achieved at a lower addition rate.